Sure Short Questions On Pathology For Interview Part – 3
Q – 101 Hamartoma is usually present at birth.
Ans- True
Q – 102 Amyloid causes renal failure.
Ans- True
Q – 103 Amyloid weakens the walls of blood vessels.
Ans- True
Q – 104 Amyloid is a basophilic substance, which can be stained with Congo red.
Ans- False
Q – 105 Amyloid occurs in medullary carcinoma of the thyroid.
Ans- True
Q – 106 Amyloid occurs in chronic inflammatory disorders.
Ans- True
Q – 107 Hyperplasia occurs in myocardium.
Ans- False
Q – 108 Hyperplasia occurs in retinal pigment epithelium.
Ans- True
Q – 109 Hyperplasia occurs in corneal endothelium.
Ans- False
Q – 110 Hyperplasia results in increased cell numbers.
Ans- True
Q – 111 Hyperplasia results in increased cell size.
Ans- True
Q – 112 In the presence of inflammation, complement proteins are raised.
Ans- True
Q – 113 In the presence of inflammation, fibrinogens are raised.
Ans- True
Q – 114 In the presence of inflammation, caeruloplasmin are raised.
Ans- True
Q – 115 In the presence of inflammation, ferritins are raised.
Ans- True
Q – 116 In the presence of inflammation, platelets are raised.
Ans- True
Q – 117 Multiple myeloma can give rise to metastatic calcification.
Ans- True
Q – 118 Pulmonary tuberculosis can give rise to metastatic calcification.
Ans- False
Q – 119 Renal failure can give rise to metastatic calcification.
Ans- True
Q – 120 Sarcoidosis can give rise to metastatic calcification.
Ans- True
Q – 121 Phthsical eye can give rise to metastatic calcification.
Ans- False
Q – 122 In cerebral infarction, the necrotic tissue is eventually replaced by Schwann cells.
Ans- False
Q – 123 In cerebral infarction, cortical blindness can result from infarction of the anterior cerebral artery.
Ans- False
Q – 124 In cerebral infarction, coagulative necrosis occurs in the brain tissue.
Ans- False
Q – 125 Cerebral infarction can result from thrombosis of the external carotid artery disease.
Ans- False
Q – 126 In cerebral infarction, the area of infarct tends to be wedge-shaped.
Ans- True
Q – 127 Factor V Leiden mutation may cause central retinal vein occlusion in a young patient.
Ans- True
Q – 128 Atrial fibrillation may cause central retinal vein occlusion in a young patient.
Ans- False
Q – 129 Antithrombin III deficiency may cause central retinal vein occlusion in a young patient.
Ans- True
Q – 130 Excess protein S may cause central retinal vein occlusion in a young patient.
Ans- False
Q – 131 Protein C deficiency may cause central retinal vein occlusion in a young patient.
Ans- True
Q – 132 In atherosclerosis, raised HDL is associated with atherosclerosis.
Ans- False
Q – 133 In atherosclerosis, proliferation of smooth muscle cells in the intima is typical.
Ans- True
Q – 134 In atherosclerosis, thinning of the intima is a feature.
Ans- False
Q – 135 In atherosclerosis, foamy macrophages are seen in type I plaque.
Ans- False
Q – 136 Atherosclerosis occurs in the retinal artery.
Ans- False
Q – 137 During wound healing, during collagen synthesis, lysine and proline are directly incorporated into the collagen molecules.
Ans- False
Q – 138 During wound healing, in infected wound collagen lysis is increase.
Ans- True
Q – 139 During wound healing, in scurvy the wound is weak due to increased activity of collagenase.
Ans- False
Q – 140 During wound healing, with absorbable suture, the wound strength decreases from the time of suturing.
Ans- True
Q – 141 During wound healing, the inflammation is greater for catgut than nylon
Ans- True
Q – 142 With regard to cell growth, achondroplasia does not affect membranous bone
Ans- True
Q – 143 With regard to cell growth, in metaplasia, there is a change of a type of differentiated cell to a type of undifferentiated cell
Ans- False
Q – 144 With regard to cell growth, the main stimulus for hypertrophy is hormonal
Ans- False
Q – 145 With regard to cell growth, hypocalcaemia can lead to enlargement of the parathyroid gland.
Ans- True
Q – 146 With regard to cell growth, ionizing radiation can cause atrophy.
Ans- True
Q – 147 The blood vessels surrounding an acutely inflamed site usually show progressive vasodilatation from the time of injury.
Ans- False
Q – 148 Autolytic changes in the nucleus are pathognomonic of necrosis.
Ans- True
Q – 149 Apoptosis does not usually cause inflammation.
Ans- True
Q – 150 Acute inflammation usually occurs around necrotic tissues.
Ans- True
Q – 151 Gangrene refers to tissue necrosis with or without infection.
Ans- False
Q – 152 The wound site becomes vascular as time passes.
Ans- False
Q – 153 Fibroblasts have a contractile function, which helps to produce a small scar.
Ans- True
Q – 154 The epidermal and dermal epithelia grow downwards along the suture track.
Ans- True
Q – 155 Monocytes clean the debris left by phagocytes.
Ans- True
Q – 156 Early suture removal does not affect the granulomatous response.
Ans- False
Q – 157 In ionizing radiation, undifferentiated tumors are usually more sensitive to radiation than differentiated tumors.
Ans- True
Q – 158 In ionizing radiation granulation tissue, formation is delayed in wounds, which have been radiated?
Ans- True
Q – 159 In ionizing radiation, cells experiencing hypoxia are vulnerable to radiation damage?
Ans- False
Q – 160 In ionizing radiation, mitosis does not occur in irradiated cells?
Ans- False
Q – 161 In ionizing radiation, cells in G1 phase of the cell cycle are most sensitive?
Ans- False
Q – 162 There are about 40 000 human genes and ESTs (expressed sequence tags) available on the Affymetrix Gene Chips for gene expression. Make some reasonable assumptions and estimate, for a normal organ, the number of genes that will appear to be expressed significantly greater than or less than the population norm (95% confidence interval).
Ans- If we assume that each gene is independent and occurs in a normally distributed population, then one might expect approximately 5% of 40 000 or 2000 genes to appear over expressed or under expressed.
Q – 163 Dr Jones is a pathologist who has recently developed a virtual microscope program for teenagers to use while they are hospitalized. He thinks that teens might use this program to learn more about their illness and the role that pathology plays in the hospital. He has heard that usability is important, so he asks a few of his colleagues to try the program out in their free time and to e-mail their comments to him. Describe 3 specific things that Dr Jones should have done differently in order; to more appropriately assess the usability of his program.
Ans- (1) Have teens test the program, not physicians;
(2) select specific representative tasks for the assessment (not just “try the program out”); and
(3) observe the participants using the program and have them think aloud during the session rather than e-mail comments.
Q – 164 To what 2 aspects of a usability assessment should the word “representative” apply?
(1) Representative tasks
(2) Representative users
Q – 165 What are the benefits of high-throughput expression analysis in molecular biological investigations?
Ans- These techniques allow simultaneous analysis of the expression of many genes. Patterns of increased or decreased expression is associated with disease may then be identified and may contribute to improved diagnosis and prognosis.
Q – 166 What is a “gene expression signature” for a tumor?
Ans- A collection of genes that are expressed consistently higher or lower in the tumor than is the population norm for non-tumorous tissue of the same type.