Latest Pharmacology Objective Questions
Q – 1 Explain Which type of immunoglobulin level will increase when an individual is exposed to a parasite?
Ans- Serum IgE levels will increase and remain until the parasite is washed out from the body.
Q – 2 Explain Dose of acetaminophen in children
5-10mg/kg/day
5-10mg/kg/dose
10-15mg/kg/day
10-15mg/kg/dose
Ans- 10-15mg/kg/dose
Q – 3 Explain with an example of haemopoietic growth factor is
platelet derived growth factor
epidermal growth factor
iron dextran
erythropoietin
Ans- erythropoietin
Q – 4 Explain Which of the following hypnotic agents is absorbed slowly?
Phenobarbital
Flurazepam
Triazolam
Temazepam
Ans- Temazepam
Q – 5 Explain Flumazenil blocks the actions of:
Phenobarbital
Morphine
Zolpidem
Ethanol
Ans- Zolpidem
Q – 6 Explain indirect-acting adrenoreceptor blocking drug:
Tolazoline
Reserpine
Carvedilol
Prazosin
Ans- Reserpine
Q – 7 Explain the hypnotic drugs induce:
Increase the duration of REM sleep
Decrease the duration of REM sleep
Do not alter the duration of REM sleep
Increase the duration of slow wave sleep
Ans- Decrease the duration of REM sleep
Q – 8 Explain Which of the following is an antifungal
Flucytosin
Cytosine arabinoside
5 fluourasil
Procarbazine
Ans- Flucytosin
Q – 9 Explain Which of the following benzodiazepines is used mainly for hypnosis?
Clonozepam
Lorazepam
Flurazepam
Midazolam
Ans- Flurazepam
Q – 10 Explain Oral contraception failure can occur with A/E:
ampicillin
phenytoin
rifampicin
mebendazole
Ans- mebendazole
Q – 11 Explain Which of the following is not used in enterococcal infection?
Vancomycin
Linezolide
Teichoplanin
Cephalexin
Ans- Cephalexin
Q – 12 Indicate a beta receptor antagonist, which has very long duration of action:
Metoprolol
Propranolol
Nadolol
Pindolol
Ans- Nadolol
Q – 13 Explain Hypnotic drugs are used to treat:
Psychosis
Sleep disorders
Narcolepsy
Parkinsonian disorders
Ans- Sleep disorders
Q – 14 Explain which of the following antitubercular drug contraindicated in pragnancy.
INH
ethambutol
rifampicin
streptomycin
Ans- streptomycin
Q – 15 MOA of moricizine:
prolongs APD
shortens APD
no change in APD
calcium channel blecker
Ans- prolongs APD
Q – 16 Indicate the irreversible alfa receptor antagonist:
Tolazoline
Labetalol
Prazosin
Phenoxybenzamine
Ans- Phenoxybenzamine
Q – 17 Explain Ciprofloxacin act by
Inhibiting protein synthesis
Inhibiting DNA function
Inhibiting cell wall synthesis
Inhibiting glycolysis?
Ans- Inhibiting DNA function
Q – 18 Explain DOC for cisplatin induced vomitting:
metaclopramide
domperidone
ondansetron
prochlorperazine
Ans- ondansetron
Q – 19 Explain Which of the following barbiturates is an ultra-short-acting drug?
Secobarbital
Amobarbital
Thiopental
Phenobarbital
Ans- Thiopental
Q – 20 Explain All of the following agents are beta receptor agonists EXCEPT:
Epinephrine
Isoproterenol
Methoxamine
Dobutamine
Ans- Methoxamine
Q – 21 Explain Do you know how the dose for children is being estimated based on preclinical data?
Ans- There are a number of ways of estimating children’s doses from preclinical (adult) data – often depends on the therapeutic index of the drug in question (the wider the therapeutic window the less accurate the child’s dose needs to be). Sometimes straight weight-basis i.e. 7kg child gets 1/10 dose of 70kg adult.
More accurate (so they say) is a dose based on body surface area (child’s surface area is greater in proportion to its body weight than an adult is). There are normograms to calculate surface area from weight and height of child.
All of these may be wrong if clearance of drug in child is significantly different from adult e.g. different metabolism or different route of clearance.